Cu-Catalyzed C–H Activation Reaction: One-Pot Direct Synthesis of Xanthine and Uric Acid Derivatives from 5-Bromouracil

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چکیده

Abstract A one-pot direct synthesis of xanthine and uric acid derivates is reported. This simple yet efficient methodology illustrates concurrent formation two C–N bonds using CuBr2 as catalyst one those formed by uracil C6–H bond activation.

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ژورنال

عنوان ژورنال: Synlett

سال: 2021

ISSN: ['0936-5214', '1437-2096']

DOI: https://doi.org/10.1055/a-1542-9683